The USC Trojans host the Notre Dame Fighting Irish on Saturday afternoon. The Trojans come into the game as home underdogs.  Did ESPN’s College GameDay crew pic

USC had the ball within one touchdown of No. 5 Notre Dame, but back-to-back interceptions returned for touchdowns sealed the Trojans' loss to the Irish.

No. 5 Notre Dame will travel to Southern California on Saturday to face USC on CBS. This matchup will mark the 95th all-time meeting between the historic programs. Notre Dame and USC have played each other every season in football since 1926,

As long as Notre Dame takes care of its business and wins, it should secure a spot in the 12-team College Football Playoff and could probably be as high as a No. 6 or 7 seed. A loss, which would be its second of the season,