The actor recalled experiencing an early symptom of multiple sclerosis while filming the smash Netflix series' pilot episode.

Speaking on the latest episode of her MeSsy podcast, which she co-hosts with Jamie-Lynn Sigler, who also has MS, Applegate explained how she fell over while filming a running sequence in a field. She didn’t realize it at the time, but this was an early sign of her MS.

The star said that she fell while running across a field during a scene for the dark comedy and now realizes it was an early sign of her autoimmune condition. “I remember falling that day,” recalled Applegate. “Hi, first sign of MS!” Feldman also remembered the incident.