After the 49ers' humiliating loss to the Bills, head coach Kyle Shanahan was asked to give his assessment of the state of the ...

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back ...

ESPN analyst and Hall of Fame wide receiver Randy Moss asked fans to pray for him and his family as he's dealing with an ...

The 49ers' goal last offseason was to strengthen their depth in pursuit of another NFC crown. That depth has been tested and ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

San Francisco 49ers offensive lineman Trent Williams was sidelined Sunday against the Buffalo Bills due to an ankle injury.

The San Francisco 49ers dropped their record to 5-7 after a 35-10 loss against the Buffalo Bills in Week 13. Today, Pro ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

The San Francisco 49ers are preparing for their Week 12 contest against the Green Bay Packers on Sunday at Lambeau Field in ...

"GMFB" on what do you make of the Buffalo Bills Week 13 "Sunday Night Football" win vs. the San Francisco 49ers.

Well, that wasn't fun. The San Francisco 49ers looked like they were cooking early in the game, but eventually, the Buffalo ...

Only a miraculous finish can save the 49ers now — and the team that's shown up recently looks completely incapable ...