Starter Christian McCaffrey (knee) is amid his second IR stint, and his backup, Jordan Mason, is also on IR with a high-ankle ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

Derrick Feldt, a 49ers fan who has beaten cancer twice, caught the attention of San Francisco star Christian McCaffrey before the Week 13 game in Buffalo and received a special gift.

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

More and more you could make an argument the most dangerous job is that of running back for the San Francisco 49ers.

Breaking down all of the good and some of the bad from the 49ers’ much-needed blowout win over the Bears in Week 14.

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

No Christian McCaffrey has been no problem for the 49ers in the first quarter of Sunday's game against the Bears.

San Francisco 49ers safety Talanoa Hufanga, defensive back Deommodore Lenoir and defensive lineman Jordan Elliott are set to ...