Speaking on the latest episode of her MeSsy podcast, which she co-hosts with Jamie-Lynn Sigler, who also has MS, Applegate explained how she fell over while filming a running sequence in a field. She didn’t realize it at the time, but this was an early sign of her MS.

Christina Applegate recalls ‘first sign of MS’ while filming Dead to Me pilot - Actor was diagnosed with the chronic nervous system disorder years after the first signs were there

Christina Applegate recently reflected on the first sign of her multiple sclerosis while filming "Dead to Me." During the Dec. 10 episode of "MeSsY" podcast, Liz Feldman, the executive producer of Netflix's show,

The actress revealed she made it through complicated scenes thanks to the support of her television friends and family.

Dead To Me' star Christina Applegate has recalled "falling" on the set of the drama, which she later realised were the first signs of MS.