The 49ers' keys to an upset in Buffalo include adjusting to snowy weather, a top-notch opposing QB, and a pre-snap ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The San Francisco 49ers are encouraged by linebacker Dre Greenlaw's progress as he works his way back from a torn Achilles ...

The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

After missing Week 12 with a shoulder injury, 49ers quarterback Brock Purdy is ready to get back on to the field. The ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

San Francisco 49ers general manager John Lynch appeared on Bay Area radio station KNBR on Friday morning to share the latest ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...