Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

The San Francisco 49ers are currently in last place in the division and in danger of missing the playoffs. The 49ers have ...

The San Francisco 49ers on Tuesday announced how they’d replace running back Christian McCaffrey. In a slew of roster moves ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

In the meantime, the 49ers claimed ex-New York Jets running back Israel Abanikanda on Tuesday, according to Schefter. "49ers ...

The 49ers shored up their suddenly thin running back corps on Tuesday by claiming Israel Abanikanda off waivers from the New ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

What has to be done for the San Francisco 49ers to have a chance at the playoffs or at the very least, a winning season in ...

The San Francisco 49ers claimed running back Israel Abanikanda off waivers from the New York Jets on Tuesday, one day after ...

The 49ers have lost three games in a row, but their season isn't dead yet. Sure, they're in last place in the NFC West, but ...