The Buffalo Bills dismantled the San Francisco 49ers 35-10 at Highmark Stadium, and clinched the AFC East in the process.

The most recent instance of a quarterback scoring on his own pass was when Marcus Mariota had his pass batted up into the air ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.

The Bills sacked Purdy twice, Greg Rousseau getting one while the other was called a team sack because Purdy lost a fumble ...

The San Francisco 49ers are preparing for their Week 12 contest against the Green Bay Packers on Sunday at Lambeau Field in ...

The San Francisco 49ers looked out of their element as the Buffalo Bills cruised to an easy 35-10 win on Sunday Night ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...

The heavy lake effect snow prompted the Buffalo Bills to ask fans for help clearing snow out of Highmark Stadium ahead of the ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

Buffalo Bills quarterback Josh Allen and wide receiver Amari Cooper broke down the unbelievable touchdown they combined for ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday Night Football, rumbling past them 35-10. Not only did this win ...

In an otherwise boring game against San Francisco -- the result of the game was never in question -- Bills quarterback Josh ...