Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

McCaffrey suffered a PCL injury during Sunday's loss to the Bills, while Mason goes on IR with a high ankle sprain.

As the San Francisco 49ers departed Buffalo in the wee hours Monday morning, they were bracing for the possibility that ...

The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

The San Francisco 49ers plan to place running backs Christian McCaffrey and Jordan Mason on injured reserve after suffering ...

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the ...

A trying season for the San Francisco 49ers took two more hits after Sunday's loss to the Buffalo Bills. The one-time ...

An extremely disappointing season for Christian McCaffrey, which encapsulates the distressing tone of the San Francisco 49ers ...

Per HC Kyle Shanahan, the 49ers are placing RB Christian McCaffrey on injured reserve due to a PCL injury in his right knee.