While the 49ers will be without left tackle Trent Williams for a fourth straight game on Thursday night, there's at least a ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

San Francisco 49ers head coach Kyle Shanahan reaffirmed his commitment to the organization after a 38-13 win over the Chicago Bears on Sunday. "I don't ...

The San Francisco 49ers sustained another injury at running back during their Sunday contest against the Chicago Bears.

San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing ...

It's the final week of byes and also the swan song for the regular season in some fantasy leagues, making for an intriguing ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

Also out is 49ers RB Christian McCaffrey, one of the NFL’s most dynamic players. He’s battled injuries all season and is now ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...